Endocrine Abstracts

The Case: We are presenting a 51-year-old Caucasian lady with known type 1 diabetes who was diagnosed with Autoimmune Addison’s Disease (AAD) during investigation of persistent hyponatremia. She was admitted with DKA back in November 2022 that was believed to be due to gastroenteritis. Usually, her diabetes control has been reasonable over the years with no severe chronic complications or diabetes-related hospital admissions. In the hospital, she suffered from ongoing hyp...

We are a presenting a 57 year old male victim of recurrent metastatic melanoma who was treated surgically in 2015 by wide local excision together with right axillary dissection for axillary nodal spread. He re-presented to dermatology clinic in December 2018 with skin lesion that was histologically proven to be a BRAF-mutant malignant melanoma. CT scans at that time showed spread to mediastinal and hilar nodes. Oncology team decided to commence Iplimumab/Nivolumab combination ...

Case History: A 71-year-old man with well controlled hypertension and left eye blindness due to congenital toxoplasma chorioretinitis presented to his GP with worsening headache. Initial CT head revealed a massive left parasellar lesion (32*25*36 mm) with suprasellar extension. Gadolinium-enhanced MRI revealed large cystic sellar mass, marked chiasmal compression and total encasement of Left carotid artery. 48 hours after MRI he was admitted acute severe right abdominal pain. ...

Background: Hyperinsulinemic hypoglycaemia (HH) after Roux-en-Y gastric bypass (RYGB) is rare. Patients typically present with post-prandial hypoglycaemia >1 year after surgery and once weight loss has plateaued. Despite multiple treatment options, the management of these patients remains challenging.Clinical case: A 31-year-old female was referred for bariatric surgery with a BMI of 41.4 kg/m2. In the year preceding the r...

Background and Aim: Type 2 diabetes mellitus (T2DM) disparately affects ethnic groups. Prevalence is higher in Asian and Black ethnicities, and these patients suffer increased rates of some diabetes-related complications. Bariatric surgery is an effective treatment for T2DM and can lead to complete diabetes remission. The aim of this study was to assess if T2DM remission rates at 1-year following bariatric surgery vary between different ethnicities.Metho...

Objectives: The long-term outcome of bariatric surgery on renal function in the morbidly obese renal transplant recipient is still unknown. We describe three cases of morbidly obese renal transplant recipients who have subsequently undergone bariatric surgery.Patient 1: A 44-year-old man (BMI 42.2 kg/m2) had received a renal transplant for chronic renal disease secondary to childhood reflux nephropathy. Laparoscopic Roux-en-Y gastric bypass re...

Objectives: The long-term outcome of bariatric surgery on renal function in the morbidly obese renal transplant recipient is still unknown. We describe three cases of morbidly obese renal transplant recipients who have subsequently undergone bariatric surgery.Patient 1: A 44-year-old man (BMI 42.2 kg/m2) had received a renal transplant for chronic renal disease secondary to childhood reflux nephropathy. Laparoscopic Roux-en-Y gastric bypass re...

Background: An increasingly recognized complication of Roux-en-Y Gastric Bypass (RYGB) surgery is the development of postprandial hypoglycaemia (PPH). However, there remains no agreed standard on how to diagnose this condition. Commonly used tests include a prolonged oral glucose tolerance test (POGTT) and mixed meal tolerance test (MMTT). Little is known regarding how these tests compare in the post-bariatric population.Methods: Ten patients who had con...

Introduction: Obesity related glomerulopathy (ORG) is an emerging epidemic alongside increasing incidences of obesity. ORG pathophysiology has not been explored despite poor prognosis in untreated patients. MCP-1, MIF, CCL-18 and CCL-15 are novel cytokines that may be pathologically involved in obesity-induced renal injury and explored in this study.Methods: Blood pressure, urine and blood samples were collected from 34 morbidly obese patients before and...

Introduction/Aims: Currently, the most successful long term treatment for obesity is bariatric surgery, however the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following bariatric surgery. We aimed to investigate changes in eating behaviour and psychological factors pre- and 1 month post-very low calorie diet (VLCD) and 3-month p...